Welcome!
Welcome to the Lindlich Lab at Charité Universitätsmedizin Berlin! Led by Dr. Steffen Lindner, our research leverages growth-coupled metabolic engineering to tackle critical challenges in bioproduction, enzyme engineering, and C1 feedstock utilization, driving sustainable and innovative solutions for industrial biotechnology.
Research Focus
01.
Growth-Coupled Bioproduction
We tailor metabolic pathways so that microbial growth is tied to the production of valuable chemicals and fuels. This growth-coupling method ensures that metabolism produces an obligatory product alongside biomass, driving efficient production as the organism can only grow by producing.
02.
Sustainable Carbon Sources
We engineer microbes to utilize substrates like lignocellulosic sugars, lignin, CO2, methanol, and formate for growth and bioproduction. This approach develops solutions necessary for the establishing of a circular bioeconomy by converting waste and renewable resources into valuable compounds, enhancing sustainability.
03.
In Vivo Enzyme Engineering
We utilize sensor strains to couple enzymatic functions to the organism’s growth. This strategy enables rapid screening of enzyme libraries and accelerates the development of optimized catalytic activities, allowing to couple to adaptive evolution and hypermutation techniques.